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Preclinical studies have demonstrated that both glycyrrhizin and silymarin exert hepatoprotective effects against oxidative stress, and their combination may produce synergistic benefits by reducing serum transaminases and enhancing antioxidant enzyme activities ( 5 Adverse reactions Pseudohyperaldosteronism is the most common adverse reaction

However, studies indicate that metformin for adolescents may increase the incidence of mild to severe gastrointestinal side effects, such as nausea, vomiting, diarrhea, and flatulence

Maurel, M., Chevet, E., Tavernier, J

I also use an oral form of glutathione frequently in my patients usually, S-Acetyl glutathione