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Patients initially received intramuscular acetyl-l-carnitine at a dose of 500 mg twice daily for an average of 57 9 days, followed by oral administration at the same dose for up to 6 months

doi: 10.1136/bmjopen-2020-039358 98

Gim thiu tnh trng au mi c vi Beta-Alanine H tr phc hi v pht trin c bp ti a vi BCAA

Importantly, these residues, including His27, Lys59 and Tyr63 in LET7 TPR mediating polar interactions with HOP1, reside on the key interaction interface with LET7 PPase in the crystal structure of LET7/ At PAPP5 (PDB ID: 7OBE) 25 , further substantiating the idea that HOP1 displaces LET7 TPR from LET7 PPase to relieve the autoinhibition of LET7 catalytic activity