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Common side effects for both include nausea, vomiting, diarrhea, and constipation
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But once it becomes approved, retatrutide may represent the most powerful therapeutic option ever introduced for severe obesity and metabolic disease.
The mean change in body weight from baseline to week 104 was 15.2% in the semaglutide group ( n = 152) versus 2.6% with placebo ( n = 152), for an estimated treatment difference of 12.6 %-points (95% confidence interval, 15.3 to 9.8
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