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In a randomized, double-blind trial where women applied GHK-Cu encapsulated in a nano-lipid carrier twice daily for 8 weeks, the treatment group saw significant improvements in wrinkle depth and volume with no serious adverse events

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Evidence GHK-Cu is associated with regulation across more than 4,000 genes, including collagen synthesis, antioxidant defense, wound healing, inflammation, and tissue breakdown

The peptide appears to interact with the dopaminergic and serotonergic systems, which may contribute to its effects on pain perception and mood