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It should not be used in people with a personal or family history of medullary thyroid carcinoma or in those with multiple endocrine neoplasia syndrome type 2, unless a doctor decides otherwise based on local guidance
First, there is a lack of standardized exercise protocols across studies, with wide variability in training type, frequency, intensity, and supervision, which limits comparability and prevents the identification of optimal regimens for preserving lean mass or enhancing metabolic outcomes
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