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At the same time, it appeared that some transcript readouts moved in different directions, which suggests that FOXO4-DRI peptide may also act as a stressor for surviving cells, potentially triggering compensatory transcriptional responses even as senescent cells are eliminated

However, patients on thyroid replacement do have a slightly elevated baseline risk of atrial fibrillation if TSH levels remain suppressed, so maintaining TSH in target range (typically 0.54.0 mIU/L) during tirzepatide therapy is important for overall cardiac safety

Some of these studies also note small, transient increases in blood pressure, particularly in the early stages of treatment