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In addition to cardiovascular benefits, dual GLP-1/amylin therapy is now being studied in various obesity-related conditions like nonalcoholic steatohepatitis, obstructive sleep apnea, chronic kidney disease, and heart failure with preserved ejection fraction, suggesting that these drugs could be used as a cornerstone therapy for the management of comprehensive metabolic syndrome rather than for just one indication

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[6] These analyses are useful, but they are the weakest tier for a two-drug verdict: indirect comparisons inherit every difference between the underlying trials and cannot substitute for a randomised head-to-head