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74 Chronic overnutrition, a sedentary lifestyle and IR in adipose tissue can directly lead to the production and accumulation of excess toxic lipid products (such as diacylglycerol, ceramides, and NEFAs), and the metabolites can aggravate the ectopic lipid deposition through some signaling pathways (such as mTOR and notch)

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It is typically prescribed for patients with a BMI of 27 or higher , especially those with weight-related conditions such as high blood pressure or diabetes