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Bmal1 and beta-cell clock are required for adaptation to circadian disruption, and their loss of function leads to oxidative stress-induced beta-cell failure in mice
Also, hormonal changes that occur at certain stages of life, such as menopause in women, can cause collagen breakdown, dryness, sagging skin and wrinkles, but also greater bone porosity and joint sensitivity
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IGF-1 LR3 and IGF DES 1,3 are two groups of IGF-1 variants, each with distinct structural and functional properties
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