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USA 116 , 1209412102 (2019)

In humans, lower levels of the de novo NAD + synthesis precursor Trp have been observed in blood samples of PD patients, indicating disruption of the kynurenine pathway 276,277

Cholinergic Toxicity

Timing Optional Monitoring guidance is trial-informed and pathway-based because cagrilintide is not an approved stand-alone medication with a mature clinical monitoring label