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What the drug-alone data does show is that mice lost fat with no change in food intake, so the effect is not simply appetite suppression
A large observational analysis presented at the ASMBS meeting suggested that bariatric surgery produced approximately 26.5% weight loss at two years compared with much lower real-world outcomes using GLP-1 medications
10.1007/s40264-020-01026-y Drug Saf
doi: 10.1016/S1474-4422(25)00175-9 388 LynchDRMathewsKDPerlmanSZesiewiczTSubramonySOmidvarOet al
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