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The hypertrophic heart can use lactate as fuel, export lactate to manage cytosolic redox state, or use lactate-derived signals to influence gene regulation
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The presence of oxidative stress markers like lipid peroxidation, neutrophil reverse trans-endothelial migration (rTEM) and high neutrophil to lymphocyte ratio in patients with COVID-19, facilitates identification of high-risk individuals early in the course of the disease preventing their sudden deterioration (Laforge et al., 2020)
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