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The combined effect is an employee benefits cost environment where medical and prescription benefits are projected to increase 8% to 10% in 2026, according to HUB Internationals research
In 2023 the firm abandoned development of lotiglipron after trial participants showed elevated liver enzymes, and the same year discontinued a twice-daily danuglipron dosing regime after almost three quarters of treated patients experienced nausea, while almost a half developed vomiting and a quarter diarrhoea
Patients following plant-based diets, older adults, or those with a history of gastrointestinal surgery face higher risk
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