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The relative contributions of each receptor to overall efficacy and tolerability are under ongoing investigation
The use of the glucagon-like peptide-1 receptor agonist (GLP-1RA), semaglutide, significantly enhanced liver health in patients with metabolic dysfunction-associated steatohepatitis (MASH) in several ways, including reducing inflammation, metabolic dysfunction, and fibrosis progression, through both weight-dependent and distinct proteomic mechanisms, according to a study published in Nature Medicine
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