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The widely repeated claim that it is ~ten-million-fold more potent than BDNF is a relative in-vitro spine-counting ratio, not a human effect, and key mechanism papers from the originating lab were retracted in 2025
Evidence from German clinical practice in an IQVIA study underscores this gap: BMI documentation was recorded for only 10.8% of patients [2] highlighting that comprehensive measurements of obesity are not being translated to clinical practice
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