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Non-randomized controlled trials and observational studies, including cohort and cross-sectional studies, were excluded from this study

Lee and Padgett 2021 The study's limitations are genuine and must be stated: it is retrospective, uncontrolled, has no placebo arm, involves patients from a clinic with commercial interest in peptide therapy, and the sample size of 16 provides insufficient statistical power to draw definitive conclusions

Intracellular calcium mishandling leads to cardiac dysfunction and ventricular arrhythmias in a mouse model of propionic acidemia