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Chemistry, structure and function of approved oligonucleotide therapeutics
Interestingly, the generation of R-2-HG from glutamine has been proven to occur rapidly in patient-derived chondrosarcoma cell lines harboring endogenous IDH mutations, indicating fundamental metabolic differences between cells that harbor IDH1/2 mutations and those that do not 121
A weak, slow, or irregular pulse might reflect insufficient Qi and blood, dysfunctional viscera, and suggest increased vulnerability to acute mountain sickness (Wang et al., 2023)
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