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While loss of p53 function may weaken the apoptotic signaling response mediated by DNA damage related to chemotherapy resistance [127], thinking about strategies to reduce side effects without compromising p53 function will be of widespread value in cancer treatment
Persistently high levels warrant medical investigation to identify any underlying cause
Busulfan Busulfan is an alkylating agent widely used in myeloablative conditioning regimens before bone marrow or hematopoietic stem cell transplantations 78
doi: 10.3389/fphar.2015.00323 11 AlammarN.WangL.SaberiB.NanavatiJ.HoltmannG.ShinoharaR
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