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Their effects likely arise from a convergence of pathways: indirectly, through systemic improvements in glycemic control and metabolism, and directly, via the activation of intraocular GLP-1Rs on cells like retinal Mller and ganglion cells, which triggers local anti-inflammatory, anti-oxidant, and anti-apoptotic responses

Others with pronounced fatty liver may gain particular advantage from glucagon receptor activation

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NVO posts elite margins (gross margin near 81%, operating margin around 41%) and remains one of only two players with a commercial oral GLP-1 already on the market