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CD19 amplifies the activation of Lyn and Src-family protein tyrosine kinases, thereby enhancing the signals generated by the B-cell antigen receptor to regulate B-cell development, activation, and differentiation (140)
That makes room for the healthiest, most viable cells
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Additionally, the metabolic capacity of Gdh1p and Gdh3p isoforms is essential in the regulation of -ketoglutarate levels that seems to be the signal also for the NCR-regulated gene expression
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