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This can dysregulate several processes, such as inhibition of -cell function, induction of apoptosis and activation of cytosolic post-translational modification (PTM) enzymes (36), which can generate a group of neoantigens called hybrid insulin peptides (HIPs) by covalently linking insulin peptides to -cell granule peptides, such as insulin c-peptide and IAPP

Cao and Picklo, 2014