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The quantitative data are presented as mean standard deviation (x s)
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For instance, disruption of circadian rhythms by repeated advances in the light-dark schedule in rodent models consistently altered expression of core clock genes such as Per2 and Bmal1, leading to impaired immune function, including reduced NK cell cytotoxicity and decreased expression of cytolytic factors like IFN, perforin, and granzyme B
Adherence to the prescribed titration schedule is fundamentalthe gradual dose escalation protocol (starting at 2.5 mg and increasing every four weeks) balances efficacy against tolerability
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