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It is normal for the solution to darken slightly over time under refrigeration, particularly due to the riboflavin content
Once administered intramuscularlytypically into the deltoid or gluteal musclehydroxocobalamin (the form most commonly used in the UK) enters the bloodstream rapidly
Conditions affecting the small intestine, such as malabsorption syndromes (celiac disease and tropical sprue), may also result in vitamin B 12 deficiency
Poor hygiene or reused needles can cause infection, and an injection placed badly can rarely irritate a nerve
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