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StructureActivity Relationship for Small Molecule Inhibitors of Nicotinamide N-Methyltransferase Journal of Medicinal Chemistry, 2017

B is needed for the production of neurotransmitters such as GABA, serotonin, and dopamine, and for glycogen breakdown and hemoglobin synthesis

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While the condition is the major cause of poor vitamin B 12 status in the elderly population, it is usually associated with atrophic gastritis, a chronic inflammation of the lining of the stomach that ultimately results in the loss of glands in the stomach (atrophy) and decreased stomach acid production (see Atrophic gastritis)