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In these situations, dosing is conservative, and symptoms are monitored closely
Long-term safety considerations differ between the medications
Reprod Nutr Develop 1988;28:1317-27
The FREEDOM-CVO and REWIND trials included injection-free GLP-1 RA with osmotic mini-pump and patients without established cardiovascular background respectively, whereas the PIONEER 6 study investigated oral semaglutide.4951 Mortality outcomes in some of these trials are encouraging, yet the results are inconsistent.49,51 GLP-1 RAs uniquely reduced nonfatal stroke events in the LEADER and SUSTAIN-6 trials.13,52 The effects were confirmed in our latest NMA (OR 0.88
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