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Semaglutide has been associated with increased expression of genes involved in adenosine monophosphate-activated protein kinase (AMPK) signaling and carnitine palmitoyltransferase 1 (CPT1)

These diseases may include amyloidosis (a rare disease in which amyloid proteins build up in organs like the heart and kidneys), sarcoidosis (a disease that involves the growth of inflammatory cells in the body), or hemochromatosis (the buildup of too much iron in the body)

Zhao H, Wu L, Yan G, Chen Y, Zhou M, Wu Y, et al

Rarely, it can cause muscle weakness in people with uremia and seizures in those with or without a history of seizure disorders