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Sex hormone-binding globulin (SHBG) levels typically increase with weight loss and improved metabolic health
Peak weight loss acceleration occurs during the dose-titration phase (weeks 4-20), with clinical trial data showing an average loss of 15-22% of baseline body weight by week 20
Sin YY, Price PR, Ballantyne LL, et al
Cardiac hypertrophy leads to heart failure at the later decompensated stage of the disease process, which is a primary cause of morbidity and mortality
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