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While healthy eating and strength training can improve muscle tone, and skin care can enhance skin quality, they cant address significant excess skin left after major weight loss

A number of other patents and patent applications contain prophetic disclosures of combination therapy where one agent is a melanocortin receptor agonist and a second agent is a PDE-5 inhibitor

These kinases are activated upon exposure to diverse extracellular stimuli, including growth factors, cytokines, and cellular stress signals

Further preclinical and clinical trials utilising these dual agonists are ongoing, though results are unpublished at the time of writing [48]