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PEG modification increased the stability of protein and peptide drugs, increased the solubility, reduced the immunogenicity, prolonged the residence time in blood, reduced the protease degradation, and reduced the frequency of drug use

The FDA responded to this study by approving Wegovy in March 2024 to reduce the risk of cardiovascular death, heart attack and stroke in adults with cardiovascular disease and either obesity or overweight

BPC-157 has been featured on popular platforms including the Joe Rogan Experience and by neuroscientist Andrew Huberman, driving significant interest among biohackers and the recovery-focused research community

(12(7)):005520 doi:10.12890/2025_005520