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PMID 23106397 "Activation of the insulin-like growth factor-1 receptor alters p27 regulation by the epidermal growth factor receptor in oral squamous carcinoma cells." ( Molecular and Cellular Endocrinology , 2013)
The treatment effect was then evaluated using Cox proportional hazard regression, with cage assignment included as a random effect and batch as a covariate, using statistical software R (version 3.4.1) with package coxme
Fourth, the severity described in terms of patient impact, not just a hemoglobin number
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