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Semaglutide is degraded by proteolytic enzymes and does not rely on hepatic cytochrome P450 metabolism, whilst topiramate undergoes limited hepatic metabolism and is primarily excreted unchanged in urine

123 As CBS and CSE use the same substrates to generate H 2 S, their function is interdependently regulated through substrate/product accumulation/depletion, which will favour one biochemical pathway over the other

The treatment difference of 17.3 percentage points versus placebo represents the largest weight reduction achieved by any pharmacotherapy in a Phase 3 trial

Novo Nordisk intends to initiate a key phase 3a clinical project, enrolling approximately 1,000 obese or overweight patients with comorbidities