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As with any emerging pharmacological agent, the establishment of a safe and effective dosage for clinical use necessitates thorough and rigorous clinical trials
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Required for 10mg doses at 10mg/mL concentration
The 2024 fusion-peptide work exists precisely because researchers recognized that native DSIPs delivery to the brain is the bottleneck, and engineered around it by fusing DSIP to a blood-brain-barrier-crossing TAT transduction domain (sequence GGGGYGRKKRRQRRR) via flexible GGGGS linkers, expressed and secreted from Pichia pastoris
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