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Although it primarily regulates bile acid, lipid, and glucose metabolism, FXR also serves as a nutrient-sensitive transcriptional repressor of autophagy through direct and indirect modulation of ATG expression

TOPLINE Novo Nordisk, Eli Lilly and Pfizer have all entered the race for FDA approval of a first-in-class oral weight loss and diabetes drug, and because pills are cheaper to manufacture, these oral weight loss drugs may signal a more affordable (and easier) alternative to drugslike Ozempic, Wegovy and Mounjarothat require injections

8.3 Manufacturing, formulation, and cost of goods From a commercial perspective, peptide therapeutics face persistent scrutiny regarding manufacturing complexity and cost of goods (Babu et al., 2021)