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Specifically, IL-1 is constitutively produced and retained in keratinocytes, but in response to several stimuli, IL-1 is released, which is essentially a primary event of inflammation

A 2025 systematic review identified 544 total articles on BPC-157 published between 1993 and 2024, but after applying inclusion criteria, only 36 studies remained eligible for analysis

These concerns were later addressed by using separate fibers for capillaries and venules and replacing astrocytes with human smooth muscle cells (Cucullo et al., Even with these advantages, DIV-BBB models were superseded by BBB-on-chip models based on nano-fabrication and microfluidic techniques (Ma et al., 2005)

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