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Unlike most peptides that are produced in glands or organs and travel to target tissues, MOTS-c originates inside the cell and acts as a local and systemic signal of mitochondrial stress and energy status

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Iron is essential for macrophage ferroptosis, with the ferroportin-membrane iron transport protein (FPN) axis representing the primary pathway regulating macrophage iron levels (52)

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This broader detoxification role is relevant in the hormonal health context because estrogen metabolism is not the only source of reactive compounds that the glutathione system must manage

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