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Food and Drug Administration (FDA) has stated that compounded drugs containing BPC 157 may cause immune system reactions, with insufficient data to assess its human safety

Numerous findings have demonstrated that peptides can alleviate neuroinflammation and thereby ameliorate cognitive impairment by modulating the levels of reactive oxygen species in the gut and the composition of the intestinal flora, and that peptides with small molecular weights have higher antioxidant capacity compared to natural proteins and can be absorbed directly in the gut (126)

While a small portion can be converted into active B12, it may replace the bodys natural stores with inactive B12

While the safety profiles appear favorable (no serious adverse events reported across thousands of subjects), this does not carry the same weight as formal safety studies conducted under regulatory oversight