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Signs of gallbladder problems, including right upper abdominal pain, jaundice, or clay-colored stools, warrant urgent assessment, as these medications can increase gallstone risk, particularly during rapid weight loss

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Initially developed as glucose-lowering therapies, both classes have shown impressive cardiovascular and kidney-protective effects [17,18]

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The second pathway uses betaine as a methyl donor, catalyzed by betaine homocysteine methyltransferase (BHMT)

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