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Vander Heiden, M
The available data is one short-duration clinical trial in surgical patients (which found it well tolerated) and early pharmacokinetic work in healthy volunteers that did not flag acute harms
First, central carbon metabolites, including amino acids, tricarboxylic acid cycle intermediates and other organic acids, nucleotides/nucleosides, sugar phosphates and others, were profiled using ion-paired chromatography in ESI-negative mode, as described previously 94
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