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Yes, non-diabetic individuals tolerate GLP-1 medications well, with safety data from thousands of participants in clinical trials
AOD-9604 Research Protocols & Administration Dosing in Published Research Research investigations have employed diverse AOD-9604 doses across species and administration routes: Rodent studies: 250-500 mcg/kg orally or intraperitoneally was most common for obesity research Rabbit models: 0.25 mg per joint for osteoarthritis studies (intra-articular injection) Pig pharmacokinetic studies: 1.5 mg/kg IV and 2 mg/kg oral for metabolism characterization Human clinical trials: Oral doses of 0.25-10 mg daily
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Ribupatide (12-week US P1b): The S-1 summary discloses that in just 12 weeks of 8 mg dosing, subjects lost 23.6% of their weight on average (efficacy analysis) ( [6] )
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