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Informed use means understanding both the benefits and potential risks
For example, macrophage specific expression of the APOE-APOC1-APOC4-APOC-II locus depends on the two 620-bp macrophage-specific multi-enhancer elements termed ME.1 and ME.2 upstream of the APOC-II promoter (33, 34)
Observational links between GLP-1 exposure, lower hs-CRP, and fewer cerebrovascular/neurodegenerative events fit this biology, although only dedicated AD trials can confirm true disease modification
In these trials, 60% were White, 6% were Black or African American, and 31% were Asian
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