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This structural modification was rationally designed to optimize binding affinity to NNMT while dramatically improving membrane permeability a critical limitation of the parent 1-MQ molecule
Plus, its just a cool concept, so I may do some case studies using the same type of sensors
Importantly, FOXO4-DRI showed no significant toxicity or impact on viability and apoptosis in normal TM3 Leydig cells, where FOXO4 expression is typically low
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