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In addition to residual cardiovascular risk despite aggressive LDL reduction, high costs limiting accessibility, and unresolved long-term safety concerns, past failures of HDL-directed therapies such as CETP inhibitors underscore the complexity of lipid biology
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2 TNXB encodes the trimeric glycoprotein Tenascin-X (TN-X), which is important for structural support of matrix macromolecular complexes, including collagen fibrils and elastic fibers
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