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Reduced production of SAM also affects the activity of the histamine-neutralizing enzyme, Histamine-N-methyl transferase, and would explain much of the food insensitivity of young children with ASD, due to the presence of histamine in a diverse range of foods
In contrast, a GSSR intermediate was detected and its decreased steady-state concentration at higher glutaredoxin concentrations was suggested to support monothiol mechanism (i) 60
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