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It is based on the pharmacokinetics of reaching steady state
Side effects may become more noticeable after dose increases
This is why a thorough medical history review matters before starting either medication
While the classical incretin concept is based on the assumption that incretin hormones such as GIP and GLP-1 reach their main endocrine target cells via the bloodstream, there is some evidence that GIP (and possibly GLP-1) can be produced in relatively small amounts in endocrine alpha-cells of the pancreas [3]
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