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However, limitations remain, including dose-escalationrelated GI intolerance, insufficient long-term safety, and currently unestablished relative potency compared with injectable GLP-1 RAs and multi-receptor peptide agonists [76]

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Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide 2 4 mg for weight management: a randomised, controlled, phase 1b trial

[20] Without medical supervision, individuals with diabetes taking such medications face a meaningful risk of low blood sugar episodes