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Insulin and leptin resistance means youre at greater risk for type II diabetes if youre overweight, sedentary or have an unhealthy lifestyle and it can happen to anyone

The clinical significance of this effect is not fully characterized, but some providers recommend that women on oral contraceptives switch to a non-oral method (patch, ring, IUD, implant) when starting GLP-1 therapy, or use backup contraception during the titration period

cSNRT was also prolonged in db/db saline mice and not significantly affected by GLP-1 treatment (Supplemental Table 2)

An earlier paper on the trial also gave no details about the placebo (Ref 7)