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Similarly, patients who have a heavier burden of diabetes, such as those who require insulin or experience complications, experience family conflict, are more likely to experience negative psychological effects [121]

A 2025 meta-analysis of four randomized controlled trials involving 27,617 participants demonstrated a 19% reduction in major adverse cardiovascular events (relative risk 0.81, 95% CI 0.74-0.88), with additional benefits for cardiovascular death and nonfatal heart attack

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particularly nausea and vomiting to support treatment continuity