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We also highlighted a dysregulation in BCAA metabolism
TSCMR differs from two-step MR in that the latter uses two MR estimates to calculate the indirect effect of the exposure on the outcome, whereas TSCMR uses one MR estimate and two variant phenotype estimates to assess the direct effect of the exposure on the outcome and attenuate confounders bias (12)
This causes vision loss that typically happens without pain
If you are losing weight consistently at 1.0 mg with manageable side effects, staying at that dose is perfectly reasonable
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