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Although the study was designed and powered to determine safety and tolerability, when we analysed volunteers in cohort 3 (200 mg/12 h) we found that volunteers with overweight or obesity showed a significant decrease in body weight in 15 days of treatment (Fig

Goodman et al., 2009) and experiments conducted on rodents (Lotocki et al., 2009

PMID: 37142877

Nonetheless, even if these are early events in the degenerative process, a sustained glial activation occurs in parallel with dopaminergic cell loss and is still evident in long-term treatment with MPTP and in the SNpc of human PD (Hebert et al., 2003