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The mechanism involves enhanced cyclic adenosine monophosphate (cAMP) production and direct pituitary somatotroph cell activation

In 2014, Alchemia Oncology initiated a study using HA-irinotecan in phase 2, a single-arm trial of FOLF(HA)iri in combination with cetuximab in second-line patients with KRAS wild-type metastatic colorectal cancer not treated with irinotecan (NCT02216487)

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